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Молекулярная структура
Tacrolimus
CAS-номер: 104987-11-3 Заказать# RT000898 Заказать Распечатать
Описание
  • Synonyms 4,5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-heptadecahydro-5,19-dihydroxy-3-; FK-506; FK506; 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine- 1,7,20,21(4H,23H)-tetrone,5,6,8,11,- 12,13,14,15,16,17,18,19,24,25,26,26ahexadecahydro- 5,19-dihydroxy-3-[(1E)-2- [(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]- 1-methylethenyl]-14,16-dimethoxy-4,10,12,18- tetramethyl-8-(2-propenyl)-,(3S,4R,5S,8R,- 9E,12S,14S,15R,16S,18R,19R,26aS)-; FR 900506; Prograf; dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-,(3S,4R,5S,8R,12S,14S,15R,16S,18R,19R,26aS)-; FK 506; Fujimycin; FR-900506; [(E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-; Tacrolimus (FK506); Tacrolimus(FK-506); Tacrolimus(FK506); Tacrolimus, FK-506; Taccrolimus; Tacrolimus [GMP]; 15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(23H)-tetrone,; Prograde metamorphismPrograf;
  • Molecular FormulaC44H69NO12
  • AppearanceWhite or off-white crystalline powder
  • Molecular Weight804.01816
  • Density1.19 g/cm3
  • Boiling Point871.7 °C at 760 mmHg
  • Melting Point113-115°C
  • Flash Point481 °C
  • Storage Temperature20°C
  • Refractive index1.549
  • SolubilityDMSO: >3 mg/mL
  • UsageAn immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca
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