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Молекулярная структура
Spironolactone
CAS-номер: 52-01-7 Заказать# RT000879 Заказать Распечатать
Описание
  • Synonyms Alderon; 3-(3-Keto-7.alpha.-acetylthio-17.beta.-hydroxy-4-androsten-17.alph a.-yl)propionic acid lactone; Uractone; Spiro(17H-cyclopenta(a)phenauthrene-17,2-(3H)-furan); Xenalon; Pregn-4-ene-21-carboxylic acid,7-(acetylthio)-17-hydroxy-3-oxo-,?- lactone,(7R,17R)-; Aldactone; 17.alpha.-Pregn-4-ene-21-carboxylic acid, 17-hydroxy-7.alpha.-mercapto-3-oxo-, .gamma.-lactone, acetate; Euteberol; Prestwick_449; Pregn-4-ene-21-carboxylic acid, 7-(acetylthio)-17-hydroxy-3-oxo-, gamma-lactone, (7alpha,17alpha)-; Spironolactone A; Urusonin; Verospirone; SC 9420; SC 15983; Spiro(17H-cyclopenta(a)phenanthrene-17,2(5H)-furan), pregn-4-ene-21-carboxylic acid deriv.; Spiro-Tablinen; Spirolang; Spironolactone [BAN:INN:JAN]; 7-alpha-Acetylthio-3-oxo-17-alpha-pregn-4-ene-21,17-beta-carbolactone;
  • EINECS200-133-6
  • Molecular FormulaC24H32O4S
  • AppearanceWhite powder.
  • Molecular Weight416.57
  • Density1.24g/cm3
  • Boiling Point597°Cat760mmHg
  • Melting Point198-207℃ (dec.)
  • Flash Point302.3°C
  • Alpha-37 o (C=1, CHCL3)
  • Storage TemperatureKeep container closed when not in use. Store in a cool, dry, well-ventilated area away from incompatible substances.
  • Refractive index-36 ° (C=1, CHCl3)
  • Solubilitypractically insoluble
  • Biological ActivityCompetitive mineralocorticoid (aldosterone) receptor antagonist that exhibits antihypertensive activity in vivo . Also displays antiandrogen activity and inhibits steroid hormone biosynthesis.
  • StabilityStable under normal temperatures and pressures.
  • UsageIt is a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat ascites in patients with liver disease, low-renin hypertension, hypok
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