Biological ActivityPotent inhibitor of multi-drug and toxin extrusion (MATE) transporters (K i values are 46 and 77 nM for human MATE2-K-HEK293 and MATE1-HEK293 cells respectively). Also inhibits dihydrofolate reductase (DHFR).
StabilityStable, but light sensitive. Combustible. Incompatible with strong oxidizing agents.
UsageDihydrofolate reductase inhibitor; generally used in combination with other antimicrobial agents. Antiprotozoal (Toxoplasma); antimalarial