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Молекулярная структура
Lovastatin
CAS-номер: 75330-75-5 Заказать# RT000583 Заказать Распечатать
Описание
  • Synonyms MK-803; Belvas; (1S-(1alpha(R),3alpha,7beta,8beta(2S,4S),8abeta))-(1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthyl) 2-methylbutanoate; Rodatin; Paschol; Artein; Butanoic acid, 2-methyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-- oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (1S-(1alpha(R*),3alpha,7beta,8beta(2S*,4S*),8abeta))-; Sivlor; MK 803; Mevinolin; Prestwick_819; Antibiotic MB 530B; Lestatin; Colevix; Lovastation; Mevinacor; Lovasterol;
  • Molecular FormulaC24H36O5
  • AppearanceWhite solid
  • Molecular Weight404.54
  • Density1.12 g/cm3
  • Boiling Point559.2 oC at 760 mmHg
  • Melting Point175℃
  • Flash Point185.3 oC
  • Storage Temperature2-8°C
  • Refractive index320 ° (C=0.5, CH3CN)
  • Solubility0.0004 mg/mL at 25 oC
  • Biological ActivityPotent, competitive inhibitor of HMG-CoA reductase (K i = 0.6 nM) therefore decreases cholesterol biosynthesis, in vitro and in vivo . Decreases CDK2, 4, 6 and cyclin E levels and induces G1 arrest and apoptosis in tumor cell lines in vitro .
  • UsageAn antihypercholesterolemic agent. A fungal metabolite, which is a potent inhibitor of HMG-CoA reductase
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