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Молекулярная структура
CAS-номер: 53-86-1 Заказать# RT000461 Заказать Распечатать
  • Synonyms indomethacin methanol solution; indomethacin crystalline; indomethacin usp; indometacin; 1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-ylacetic acid
  • EINECS200-186-5
  • Molecular FormulaC19H16ClNO4
  • AppearanceWhite crystalline powder
  • Molecular Weight357.79
  • Density1.32g/cm3
  • Boiling Point499.4 °C at 760 mmHg
  • Melting Point155-162℃
  • Flash Point255.8 °C
  • Storage TemperatureKeep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
  • SolubilityInsoluble
  • Biological ActivityCyclooxgenase (COX) inhibitor; displays selectivity for COX-1 (IC 50 values are 230 and 630 nM for human COX-1 and COX-2 respectively). Widely used anti-inflammatory agent.
  • StabilityStable. Incompatible with strong oxidizing agents.
  • UsageInhibits cyclooxygenase (IC50=0.1uM) selectively over liposygenases (IC50=100uM for 5-,12- and 15-LO). A clinically useful NAISD

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