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Молекулярная структура
CAS-номер: 7689-03-4 Заказать# RT000063 Заказать Распечатать
  • Synonyms 4-Ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; (+)-Camptothecin; Camptothecin, Camptotheca acuminata; 4-Ethyl-4-hydroxy-1H-pyrano-[3,4:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; Camptothecin,95%; Camptothecin; 4-Ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; Camptothecin; (S)-4-ethyl-4-hydroxy-1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
  • EINECS444-280-6
  • Molecular FormulaC20H16N2O4
  • Appearancelight yellow crystal powde
  • Molecular Weight348.36
  • Density1.51 g/cm3
  • Boiling Point264°C
  • Melting Point260°C
  • Flash Point411.6 °C
  • Storage Temperature2-8°C
  • Refractive index1.787
  • Solubilityinsoluble in water,chloroform/methanol (4:1): 4 mg/mL
  • Biological ActivityCytotoxic plant alkaloid with antitumor properties; prototypic DNA topoisomerase I inhibitor.
  • UsageAntitumor alkaloid. Binds irreversible to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. A cytotoxic antitumor agent

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