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Молекулярная структура
Sunitinib Malate
CAS-номер: 341031-54-7 Заказать# RT000895 Заказать Распечатать
Описание
  • Synonyms N-(2-diethylaminoethyl)-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide; (2S)-2-hydroxybutanedioic acid; Butanedioic acid, hydroxy-, (2S)-, compd. with N-(2-(diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (1:1); PHA-290940AD; 1H-Pyrrole-3-carboxamide, N-(2-(diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-, (2S)-hydroxybutanedioate (1:1); Sunitinib malate [USAN]; SU011248 L-malate salt; SU010398; SU 011248; Sunitinib malate(TINIBS);
  • Molecular FormulaC22H27FN4O2.C4H6O5
  • Molecular Weight532.56
  • Density1.229g/cm3
  • Boiling Point572.1°Cat760mmHg
  • Flash Point299.8°C
  • Biological ActivityPotent, ATP-competitive VEGFR, PDGFR β and KIT inhibitor (K i values are 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFR β and KIT respectively). Also inhibits cellular receptor phosphorylation of FLT3, RET and CSF-1R. Exhibits antiangiogenic and antitum
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