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Молекулярная структура
Leflunomide
CAS-номер: 75706-12-6 Арт.# RT000548 Заказать Распечатать
Описание
  • Synonyms 4-Isoxazolecarboxamide, 5-methyl-N-(4-(trifluoromethyl)phenyl)-; N-(4-Trifluoromethylphenyl)-5-methylisoxazole-4-carboxamide; Leflunomidum [INN-Latin]; sell leflunomide; 5-methyl-N-[4-(trifluoromethyl)phenyl]oxazole-4-carboxamide; 5-Methylisoxazole-4-(4-trifluoromethyl) carboxanilide; Leflunamide; Isoxazole-4-carboxamide, 5-methyl-N-[4-(trifluoromethyl)phenyl]-; 5-Methylisoxazole-4-carboxylic acid (4-trifluoromethyl)anilide; Arava; Leflunomida [INN-Spanish];
  • Molecular FormulaC12H9F3N2O2
  • Appearanceoff white crystalline solid
  • Molecular Weight270.21
  • Density1.392 g/cm3
  • Boiling Point289.3 °C at 760 mmHg
  • Melting Point163-168℃
  • Flash Point128.8 °C
  • Storage Temperature2-8°C
  • SolubilityInsoluble
  • Biological ActivityImmunosuppressant agent. In vitro the active metabolite A77 1726 (RS-61980) inhibits dihydroorotate dehydrogenase (K i = 2.7 μ M) and de novo pyrimidine synthesis in T-cells; blocks lymphocyte cell cycle progression and proliferation. A77 1726 also inhibi
  • UsageAn immunosuppressive. Inhibits T and B cell proliferation. Activity is attributed mainly to its metabolite, a malononitrile derivative, which is beleived to inhibit dihydroorotate dehydrogenase as well as several protein tyrosine kinases. Therape
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