Biological ActivityPlant-derived alkaloid that binds to tubulin and depolymerizes microtubules.
StabilityStable. Light sensitive. Incompatible with strong oxidizing agents.
UsageAn antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signal