Solubilityinsoluble in water,chloroform/methanol (4:1): 4 mg/mL
Biological ActivityCytotoxic plant alkaloid with antitumor properties; prototypic DNA topoisomerase I inhibitor.
UsageAntitumor alkaloid. Binds irreversible to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. A cytotoxic antitumor agent